Next Generation Sequencing (NGS)

next generation sequencing dnaBiomolecular Discovery Services now offers next generation sequencing (NGS) in combination with selections based on synthetic, naïve or custom-immunized VHH phage display libraries. Instead of tens or even hundreds of possible leads, NGS provides you with tens of thousands of sequences rank-ordered by their prevalence in the selection. This is especially important when there are immunodominant sequences that repeatedly arise from standard selections. By doing parallel selections, you can discover VHH to common epitopes and unique epitopes and eliminate VHH to tags or fusion proteins. In combination with affinity maturation selections, you can find which residues are critical for improved binding. By altering binding conditions, you can determine which residues are affected by the change (salt, temperature, epitope mutations). 

Contact Us Today for More Information

Learn more about our next generation sequencing by contacting us today. The form is easy to fill out, and we'll be happy to get back to you with answers to any questions you may have and any other information you require before we get started.


Looking for Something Else?

Is NGS not quite the service you're looking for? Browse our other services around our synthetic and naive libraries or our antibody maturation and engineering. Our other services include: