Improving Antibody Affinity Through Affinity Maturation

Biomolecular Discovery Services Serving the United States

One of the most common problems with an antibody with the desired specificity is that the affinity is insufficient. It is not uncommon for antibodies selected from Naïve libraries to require antibody affinity maturation to improve this. However, existing antibodies can also improve their affinity with this approach. If the sequence is known, our team can work with a full-length monoclonal antibody to improve the affinity.  

A specific antibody library is typically made of the antibody of interest with random mutations, some of which will result in improved affinity. The library is selected under appropriate conditions, and the resulting molecules are further characterized by their affinity compared to the parent molecule. Specific regions can also be targeted for mutagenesis as well to undergo our affinity maturation services.


Learn More About Our Antibody Affinity Maturation Services Today

Contact our team at Biomolecular Discovery Services today to learn more about our available antibody affinity maturation services. We'll be happy to get back to you with more information about our antibody services and Naive library.

Antibody Affinity Maturation Services Through the Use of Naive Libraries

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About Our Other Services

If antibody affinity maturation isn't what you want, consider our other antibody development and learn more about our synthetic VHH libraries. Some of our antibody development services include: