Improving Antibody Affinity Through Affinity Maturation

One of the most common problems with an antibody that has the desired specificity is that the affinity is not sufficient. It is not uncommon for antibodies selected from Naïve libraries to require antibody affinity maturation. However, existing antibodies can also have their affinity improved by us with this approach as well. We can work with a full-length monoclonal antibody if the sequence is known.  

A specific antibody library is typically made of the antibody of interest with random mutations, some of which will result in improved affinity. The library is selected under appropriate conditions and the resulting molecules are further characterized for their resulting affinity compared to the parent molecule. Specific regions can also be targeted for mutagenesis as well.


Learn More About Our Antibody Affinity Maturation Services Today

Contact our team at Biomolecular Discovery Services today to learn more about our available antibody affinity maturation services. We'll be happy to get back to you with more information about our antibody services and our Naive library.

Antibody Affinity Maturation Services Through the Use of Naive Libraries

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About Our Other Services

If antibody affinity maturation isn't what you're looking for, consider our other antibody development and learn more about our synthetic VHH libraries. Some of our antibody development services include: